Fondation DigestSciences -> 02/07/2018–30/06/2023
Crohn’s Disease (CD) is a chronic disease with unknown cause, evolving in a relapsing-remitting pattern, characterized by an uncontrolled over-activation of the intestinal immune system. It is a multifactorial disease implicating genetic and predominately environmental risk factors. Urbanization of societies, diet change, hygiene status, change in farming practice, pollution and microbial exposures have been implicated as potential environmental risk factors for CD. Different changes in environmental factors might occur in various geographical areas and populations; consequently, it is important to consider both the heterogeneity and the common history of risk factors in “epidemic CD areas”. Using the world’s largest population-based study on CD incidence (EPIMAD Registry), we identified in Northern France 4 clusters of very high incidence of CD, considered as “epidemic areas of CD”, including a total of 2 310 CD patients. Epimad Registry only reports data at the time of CD diagnosis and currently includes near of 20 000 CD incident cases since 1988. The excess risk presents in these areas could be due to some variations in life style, economic, social and cultural context, as linked to exposure of pollutants. Therefore, the analysis of these clusters represents a great opportunity to identify new environmental etiological factors of CD.
Responsable : Corinne Bower (CHRU, ULille)
Partenaire : Béatrice Touchelay (IRHiS)